Natural Products: Alternate Therapeutic as Quorum Sensing (QS) Inhibitors

Microbial biofilms are essential for the survival of microorganisms in harsh environments, but they can also cause antimicrobial resistance. This book discusses the mechanism of biofilm formation and the role of quorum sensing in genetic regulation. It provides a comprehensive review of the latest pharmacological developments in antibiofilm remedies involving biogenic compounds. It is a valuable resource for researchers and students studying microbiology and microbial biotechnology.

Format: Hardback
Length: 222 pages
Publication date: 01 December 2023
Publisher: Taylor & Francis Ltd

Microbial biofilms are crucial components of the life cycles of microorganisms thriving in diverse and challenging environments, including extreme temperatures, pH levels, salinity, and nutrient scarcity. These intricate structures, formed by the aggregation of microorganisms within an outer polymer layer, serve as a survival strategy that enables colonization in new niches. The formation of biofilms involves the dispersion of microbes from clusters embedded within this protective layer, composed of extracellular polymeric substances (EPS). These EPS provide a nurturing environment for the indwelling microbes, allowing them to grow and divide while shielding them from external threats such as antimicrobial agents, surfactants, biocides, and phagocytic cells of host organisms.

The EPS matrix acts as a barrier, preventing the penetration of antimicrobials and thus enabling the indwelling microbes to survive and proliferate. However, this protective shield can also contribute to the development of antimicrobial resistance, posing a significant threat to human health. The present book delves into a comprehensive analysis of the mechanism of biofilm formation in both Gram-positive and Gram-negative bacteria, highlighting the role of quorum sensing signaling mechanisms in the genetic regulation pathway.

In addition, the book titled "Natural Products: Alternative Therapeutics as Quorum Sensing (QS) Inhibitors" provides a detailed and systematic review of quorum sensing in both Gram-positive and Gram-negative bacteria. It explores alternative pharmacological developments involving biogenic compounds as potent solutions to combat the rise of antimicrobial resistance during biofilm formation.

Key Features:

Comprehensive Overview of Quorum Sensing Mechanism in Microbial Biofilm Development: The book offers a comprehensive overview of quorum sensing, a communication system used by bacteria to coordinate various behaviors, including biofilm formation. It discusses the mechanisms by which bacteria detect and respond to environmental signals, leading to the formation of biofilms.

Biofilm Formation and Its Role in Antimicrobial Resistance: The book emphasizes the connection between biofilm formation and the emergence of antimicrobial resistance. It explores how biofilms provide a protective environment for bacteria, making them more resistant to antibiotics and other antimicrobial agents. It also discusses the strategies employed by bacteria to evade antimicrobial treatments and the implications of this resistance on human health.

Recent Pharmacological Developments in Antibiofilm Remedies: The book highlights recent pharmacological developments involving biogenic compounds as antibiofilm remedies. It discusses the use of natural products, such as plant extracts, essential oils, and compounds derived from microorganisms, as potential agents to disrupt biofilm formation and combat antimicrobial resistance.

Reference Book for Researchers: The book serves as a valuable reference book for researchers investigating the progress in understanding microbial biofilms, quorum sensing, and alternative therapeutics. It provides a comprehensive collection of information and insights that will aid in the development of new strategies and treatments for biofilm-related infections and antimicrobial resistance.

In conclusion, microbial biofilms play a significant role in the survival and adaptability of microorganisms in diverse environments. Understanding the mechanism of biofilm formation and the role of quorum sensing in antimicrobial resistance is crucial for developing effective strategies to combat these threats. The present book provides a comprehensive analysis of these topics and highlights recent pharmacological developments as potential solutions to combat the rise of antimicrobial resistance during biofilm formation.

Weight: 610g
Dimension: 229 x 152 (mm)
ISBN-13: 9781032292380